Ziconotide Acetate CAS 107452-89-1 Treat For Postherpetic neuralgia and cancer pain

Ziconotide Acetate CAS 107452-89-1 Treat For Postherpetic neuralgia and cancer pain

Product Name: Ziconotide acetate
Synonyms: OMEGA-CONOTOXIN MVIIA;OMEGA-CGTX MVII A;ZICONOTIDE ACETATE;snx111;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25);CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2;CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25)
CAS: 107452-89-1
MF: C102H172N36O32S7
MW: 2639.13
EINECS:
Product Categories: Peptide
Mol File: 107452-89-1.mol

Ziconotide (Prialt) is a 25 amino acid, three disulfide-bonded peptide toxin compound derived from the South Pacific marine snail Conusmagus. It is the first novel neurotherapeutic agent – N-type calcium channel blocker (NCCB). It selectively acts on N-type electrosensitive Chemicalbook calcium channels in dendritic and axonal terminal branches, thereby inhibiting initial injury stimulus afferents. It is indicated for patients with severe chronic pain who require intrathecal treatment and who are intolerant to or have poor efficacy of other analgesic treatments (e.g., application of systemic analgesics or intrathecal morphine). Intrathecal ziconotide can be used to treat postherpetic neuralgia, phantom limb pain, HIV-related neuropathic pain, refractory cancer pain, and post-surgical pain.

Ziconotide Acetate CAS 107452-89-1 Chemical Properties
density 1.60±0.1 g/cm3(Predicted)
storage temp. -20°C
InChIKey BPKIMPVREBSLAJ-QTBYCLKRSA-N

Uses of Ziconotide Acetate CAS 107452-89-1
Ligand for binding studies of voltage sensitive calcium channels.

Ziconotide (SNX-111; Prialt), also called intrathecal ziconotide (ITZ) because of its administration route, is an atypical analgesic agent for the amelioration of severe and chronic pain. Derived from Conus magus, a cone snail, it is the synthetic form of an ω-conotoxin peptide.[1] It is 1,000 times as powerful as morphinie.

This product is suitable for patients with severe chronic pain who require intrathecal treatment and who are intolerant or have poor efficacy to other analgesic treatments (such as the application of systemic analgesics or intrathecal injection of morphine, etc.).

Function and Application of Ziconotide Acetate CAS 107452-89-1
1. Analgesic efficacy Ziconotide is suitable for chronic pain patients who cannot tolerate or do not respond to other treatments, including systemic medication, adjuvant treatment of intrathecal injection of morphine. Intrathecal injection of ziconotide has clinically and statistically significant analgesic efficacy in patients with cancer or AIDS.

2. Spinal cord protection Short-term spinal cord ischemia When spinal cord neurons are damaged, there is N-type electrosensitive calcium pathway activation. Ziconotide can provide neuroprotection and analgesia during aortic surgery.