Puya Supply Cilengitide CAS 188968-51-6 For Lab Research

Puya Supply Cilengitide CAS 188968-51-6 For Lab Research

Product Name: cilengitide
Sequence: cyclo(Arg-Gly-Asp-D-Phe-N-Me-Val)
Synonyms: 2-[(2S,5R,8S,11S)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-7-methyl-3,6,9,12,15-pentaoxo-8-propan-2-yl-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid;Cyclo(L-arginylglycyl-L-aspartyl-D-phenylalanyl-N-methyl-L-valyl);Cilengitide(EMD121974,NSC-707544);Cilengitide;C(RGDf-Me-V);EMD 121974;EMD-121974;EMD121974;CS-1500;CS-2674
CAS: 188968-51-6
MF: C27H40N8O7
MW: 588.66
EINECS:
Product Categories: Inhibitors
Mol File: 188968-51-6.mol

Cilengitide is a cyclic peptide containing the RGD sequence. The peptide is based on the αv β3 integrin ligand in vivo and was obtained by a combination of cyclization, spatial screening and methylation scanning, with high affinity and selectivity for αv β3 integrins. Tests have shown that the peptide not only can better inhibit the growth of melanoma and glioblastoma, but also can improve the cure rate of other tumors such as head and neck squamous cell tumors in combination with radiation therapy, which has a good market prospect and potential. In peptide synthesis, Cilengitide was produced by combining solid phase peptide synthesis technology with liquid phase peptide synthesis technology.

cilengitide CAS 188968-51-6 Chemical Properties
density 1.41±0.1 g/cm3(Predicted)
storage temp. -20°C
form powder
pka 4.01±0.10(Predicted)
color white to beige

Uses of cilengitide CAS 188968-51-6
Angiogenesis inhibitor.