Puya Supply Cetrorelix Acetate CAS 120287-85-6 Luteinizing hormone-releasing hormone inhibitor (LH-RH) receptor antagonist

Puya Supply Cetrorelix Acetate CAS 120287-85-6 Luteinizing hormone-releasing hormone inhibitor (LH-RH) receptor antagonist

Product Name: Cetrorelix acetate
Synonyms: AC-(D-ALA[3-(2-NAPHTHYL)])-[D-PHE(4-CL)]-(D-ALA[3-(3-PYRIDYL)])-SER-TYR-(D-CIT)-LEU-ARG-PRO-D-ALA-OH;Cetrorelix acetate;CETRORELIX;CETRORELIX ACID;CETRIZINEDIHYDROCHLORIDE;N-Acetyl-3-(2-naphthalenyl)-D-Ala-4-chloro-D-Phe-3-(3-pyridyl)-D-Ala-L-Ser-L-Tyr-N5-(aminocarbonyl)-D-Orn-L-Leu-L-Arg-L-Pro-D-Ala-NH2;Cetrorelixum;Cetrorelixum [inn-latin]
CAS: 120287-85-6
MF: C70H92ClN17O14
MW: 1431.04
EINECS: 686-384-6
Product Categories: Peptide
Mol File: 120287-85-6.mol

Cetrorelix was launched in Germany for the treatment of female infertility. It is a decapeptidic analog of luteinizing hormone-releasing hormone (LH-RH) bearing structural modifications in the crucial positions 1, 2, 3, 6 and 10 : [Ac-D-Nal1, D-4-CI Phe-2, D-Pal3, D-Cit6, D-Alal0]-GnRH. Cetrorelix is an extremely potent and long acting gonadotrophin releasing hormone (GnRH) antagonist and thus blocks gonadotrophins and sex steroid secretion immediately after administration. Moreover, it has a low histamine-releasing potency. Cetrorelix will be the first LH-RH antagonist approved worldwide. In several Phase III clinical trials, female patients receiving Cetrorelix had a successful controlled ovulation thus avoiding a premature LH-surge. Cetrorelix could be a first-choice in-vitro fertilization (IVF) treatment without the complications of current controlled ovarian hyperstimulation protocols. Cetrorelix is currently under clinical investigation for the treatment of diverse sex hormone dependent disorders such as benign prostate hypertrophy, breast, ovarian or prostate cancers and diverse gynaecological disorders.

Cetrorelix acetate Chemical Properties of Cetrorelix Acetate CAS 120287-85-6
density 1.42±0.1 g/cm3(Predicted)
pka 9.82±0.15(Predicted)

Function and Application of Cetrorelix Acetate CAS 120287-85-6
Cetrorelix Acetate, also often referred to as cetrorelix, is a potent luteinizing hormone-releasing hormone inhibitor (LChemicalbookH-RH) receptor antagonist that controls ovarian stimulation, prevents premature expulsion of immature follicles, and aids conception, and is therefore often used as an injectable cetrorelix preparation.