Puya Supply Calcitonin salmon CAS 47931-85-1 For Osteoporosis

Puya Supply Calcitonin salmon CAS 47931-85-1 For Osteoporosis

Product Name: Calcitonin salmon
Synonyms: salmoncalcitonin-(i-32);salmoncalcitonini;tz-ct;Salmon Calcitonin Acetate;Salcatonin;CALCITONIN SALMON 250 UG;CalcitoninAcetate;Salmon Calcium
Sequence: H-[Cys-Ser-Asn-Leu-Ser-Thr-Cys]-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Gly-Thr-Pro-NH2，(Disulfide bridge: Cys1-Cys7)
CAS: 47931-85-1
MF: C145H240N44O48S2
MW: 3431.85
EINECS: 256-342-8
Product Categories: Amino Acid Derivatives;Peptide;Calcitonin and CGRP receptor
Mol File: 47931-85-1.mol

Calcitonin Salmon is a polypeptide hormone secreted by the ultimobranchial gland of salmon. It belongs to the calcitonin-like protein family and can be used to treat Paget’s disease of bone, postmenopausal osteoporosis(fragile or brittle bones), or high levels of calcium in the blood (hypercalcemia). It appears to have actions essentially identical to calcitonins of mammalian origin, but its potency per mg is greater and it has a longer duration of action. It works mainly by Inhibiting osteoclastic bone resorption, decreasing serum calcium, and increasing renal excretion of phosphate, calcium, sodium magnesium and potassium by decreasing tubular reabsorption.

Natural calcitonin is a bioactive peptide secreted by the parathyroid cells of mammals or the hind gills of vertebrates, and is the main regulator of calcium metabolism in living organisms. Salmon calcitonin acetate is a synthetic 32-peptide, and in clinical research, salmon calcitonin has been widely used in the clinic as a preventive and curative drug for osteoporosis and other metabolic bone diseases.

Chemical Properties of Calcitonin salmon CAS 47931-85-1
Calcitonin salmon Chemical Properties
density 1.54±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility 0.05 M acetic acid: 1 mg/mL, clear, colorless
form powder
Water Solubility Soluble in water at 1mg/ml
Merck 13,1642
InChIKey IYTKRMFJECGBRF-LXQLIYPUSA-N
CAS DataBase Reference 47931-85-1(CAS DataBase Reference)

Function and Application of Calcitonin salmon CAS 47931-85-1
1. Calcitonin salmon can be used for calcitonin receptor/cAMP assay for assessing the presence of calcitonin receptors expressed by TRAP+ cells.The product can also be used as a test compound for studying as well as comparing the impact of calcitonin gene related peptide (CGRP) and salmon calcitonin (sCT) on gastric mucosal barrier in rats exposed to cold + restraint stress (CRS). [sigma-aldrich]
2. Calcitonin, Salmon is a calcium regulating hormone secreted from mammalian thyroid parafollicular cells and in non-mammalian species from the ultimobranchial gland. Calcitonins are single chain polypeptides containing 32 amino-acid residues, showing hypocalcaemic and hypophosphatemic action, with amino-acid structure differing amongst mammalian species. Salmon calcitonin (salcatonin is the synthetic analogue) shows a markedly different sequence to that of the higher vertebrates as well as more potent activity. Eel calcitonin (Elcatonin) possesses a similar amino acid to that of the salmon form but is more stable than natural calcitonins because of the absence of disulfide bridges. [Santa Cruz Biotechnology]
3. It shows hypocalcaemic and hypophosphatemic action, with amino-acid structure differing amongst mammalian species. Salmon calcitonin (salcatonin is the synthetic analogue) shows a markedly different sequence to that of the higher vertebrates as well as more potent activity. It decreases blood calcium and phosphate due to inhibition of resorption by osteoblasts and osteocytes. [alfa-aesar]
4. Calcium-regulating peptide hormone released from the thyroid. Lowers calcium concentration in the blood and decreases bone resorption by osteoclasts. Used for therapeutic applications in osteoporosis. Salmon calcitonin peptide sequence differs from mammalian but is more potent.[Enzo Life Sciences, Inc.]

Uses of Calcitonin salmon CAS 47931-85-1
Osteoporosis;Hypercalcemia; Paget’s disease ; Reflex sympathetic dystrophy (algodistrophy or Sudeck’s disease)