Linaclotide CAS 851199-59-2 For Treat constipated irritable bowel syndrome (IBS-C) and chronic idiopathic constipation (CIC)
Product Name: Linaclotide
Synonyms: Linacllotide;Linaclotide;Linaelotide Acetate;Linaelotide;CY-14;Liclotide;Argpessin;L-Tyrosine, L-cysteinyl-L-cysteinyl-L-α-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-threonylglycyl-L-cysteinyl-, cyclic (1→6),(2→10),(5→13)-tris(disulfide)
CAS: 851199-59-2
MF: C59H79N15O21S6
MW: 1526.74
EINECS:
Product Categories: Inhibitors
Mol File: 851199-59-2.mol
Specification of Linaclotide
| Contents of testing | Specifications | ||
| Appearance | White or almost white crystalline powder | ||
| Identity by HPLC | The reaction is same with the reference substance | ||
| Amino Acid Composition | ±20% of theoretical | ||
| Purity (HPLC) | ≥ 98.0% | ||
| Related Substance(By HPLC) | Total Impurities(%)≤ 2.0% Largest Single Impurity(%)≤ 1.0% |
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| Acetate Content(By HPLC) | ≤15% | ||
| Water Content(By HPLC) | ≤5.0% | ||
| Bacterial Endotoxins | ≤5IU/mg | ||
Fuction and Application of Linaclotide
Linaclotide is a peptide agonist of the guanylate cyclase 2C.
This compound reduces the activation of colonic sensory neurons, reducing pain; and activates colonic motor neurons, which increases smooth muscle contraction and thus promotes bowel movements.
It was approved by the FDA in August 2012 for the treatment of chronic idiopathic constipation and constipation-predominant irritable bowel syndrome (IBS-C) in adults.
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