Icatibant Acetate CAS 30308-48-4 Use For Treat Hereditary angioedema

Icatibant Acetate CAS 30308-48-4 Use For Treat Hereditary angioedema

Product Name: Icatibant Acetate
Synonyms: Icatibant Acetate;Icatibant Impurity;Itibantide Acetate
CAS: 130308-48-4
Sequence: H-D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-D-Tic-Oic-Arg-OH
Molecular formula: C59H89N19O13S
Molecular weight: 1304.54

Eltebante, a selective competitive antagonist at the bradykinin type 2 (B2) receptor, is a decapeptide with a bradykinin-like structure with five non-protein-derived amino acids. Eltebante was approved for marketing in the EU as early as November 1, 2010 for the treatment of acute attacks of hereditary angioedema (HAE).

Function and Application of Icatibant Acetate CAS 30308-48-4
Eltebante acetate is a potent and selective competitive antagonist of bradykinin type 2 (B2) receptors that treats the local swelling of emboli in acute HAE by inhibiting the effects of bradykinin associated with the embolic local swelling, inflammation, and painful symptoms of HAE. HAE is only the first of several indications that may be treated with eltebante acetate; other potential indications are asthma, cirrhosis, and other types of angioedema.