High Quality Peptide Somatostatin Acetate/ 15-28-Somatostatin-28 CAS 38916-34-6

High Quality Peptide Somatostatin Acetate/ 15-28-Somatostatin-28 CAS 38916-34-6

Product Name: Somatostatin Acetate/ 15-28-Somatostatin-28
Synonyms: Ala-Gly-Cys-Lys-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Thr-Ser-Cys-OH;SoMatotropin Release-Inhibiting Factor, SRIF, SRIF-14;Cyclic somatostatin;SoMatostatin Acetat;GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE);GROWTH HORMONE RELEASE INHIBITING FACTOR (HUMAN, OVINE, PORCINE, RAT, MOUSE) 2ACOH 6H2O;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH;H-ALA-GLY-CYS-LYS-ASN-PHE-PHE-TRP-LYS-THR-PHE-THR-SER-CYS-OH (COUPLED TO BSA)
CAS: 38916-34-6
MF: C76H104N18O19S2
MW: 1637.88
EINECS: 254-186-5
Product Categories: Amino Acid Derivatives;Amino Acids & Derivatives;Peptide;Amino Acids 13C, 2H, 15N;Intermediates & Fine Chemicals;Pharmaceuticals;peptides pharm
Mol File: 38916-34-6.mol

Somatostatin is a cyclic 14-peptide that was first isolated by Guillemin in 1973 and is probably the most thoroughly investigated and most important of the inhibitory factors produced by the hypothalamus. The principal activity of somatostatin, which is of hypothalamic origin, is inhibition of the release of growth hormone (GH) from the anterior pituitary. Too much GH, as in pituitary tumors, causes acromegaly, a form of giantism. On the other hand, too little GH leads to dwarfism. Somatostatin also has been found in the pancreas and the GI tract, where it inhibits the secretion of both insulin and glucagon from the pancreas as well as the secretion of a variety of intestinal peptides (e.g., gastrin, secretin, pepsin, and renin). The short half-life of somatostatin, which is less than 3 minutes, has precluded its use as a therapeutic agent. Many derivatives of somatostatin have been prepared to increase its duration of action and/or to enhance its selectivity of action. The culmination of these structure–activity studies was the development of octreotide acetate.

In addition to the hypothalamus, other parts such as the cerebral cortex, striatum, amygdala, hippocampus, and spinal cord, sympathetic nerve, gastrointestinal, islet, kidney, thyroid and parathyroid glands are widely distributed in somatostatin. In the brain and gastrointestinal tract, 28 amino acids of GHRIH28, which is an outward extension of the N-terminus of GHRIH14, was purified. The effect of somatostatin in vitro is complicated, and it may act as a transmitter or modulate in the nervous system; somatostatin has a certain inhibitory effect on gastrointestinal motility and secretion of digestive tract hormones; it also inhibits insulin and pancreas Glucagon, renin, parathyroid hormone and calcitonin secretion.

Somatostatin Acetate/15-28-Somatostatin-28 CAS 38916-34-6 Chemical Properties
15-28-Somatostatin-28 Chemical Properties
Boiling point 1970.9±65.0 °C(Predicted)
density 1.43±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility H2O: 1 mg/mL
pka 2.94±0.70(Predicted)
form powder
Water Solubility Soluble in water(25,00°C 1,00 g/L), Methanol.
Merck 13,8788
BRN 6436064
InChIKey NHXLMOGPVYXJNR-ATOGVRKGSA-N

Function and Application of Somatostatin Acetate/15-28-Somatostatin-28 CAS

1 It can inhibit the secretion of growth hormone, thyroid stimulating hormone, insulin, glucagon.

2 It can inhibit gastric acid secretion stimulated by the test meal and 5-peptide gastrin, and can inhibit the release of pepsin and gastrin.

3 It can significantly reduce visceral blood flow, reduce portal pressure, reduce blood flow and pressure of collateral circulation, reduce liver blood flow.

4 It reduce the secretion of the pancreas and the secretion of the small intestine and gallbladder, reduce the enzyme activity, and have a protective effect on pancreatic cells.

5 It can affect the absorption and nutritional function of the gastrointestinal tract.