High Quality Goserelin Acetate CAS 145781-92-6 Used For Treat Breast Cancer

High Quality Goserelin Acetate CAS 145781-92-6 Used For Treat Breast Cancer

Product Name: Goserelin acetate
Synonyms: PYR-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZAGLY-NH2;[(T-BU)DSER6, (AZA)GLY10]-LH-RH;[(T-BU)DSER6, (AZA)GLY10]-LUTEINIZING HORMONE-RELEASING HORMONE;ICI-118630 acetate;GOSERELIN HCL[PYR-HIS-TRP-SER-TYR-D-SER(T-BU)-LEU-ARG-PRO-AZAGLY-NH2];1-9-Luteinizing hormone-releasing factor (swine), 6-(o-(1,1-dimethylethyl)-D-serine)-, 2-(aminocarbonyl)hydrazide, acetate (salt);Fertilan;GLP-HIS-TRP-SER-TYR-D-SER(TBU)-LEU-ARG-PRO-AZA-GLY-NH2
CAS: 145781-92-6
MF: C59H84N18O14
MW: 1269.41
EINECS: 652-995-1
Product Categories: Peptide;Pepetides;Amino Acid Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals
Mol File: 145781-92-6.mol

Goserelin acetate, like leuprolide acetate, is a synthetic superagonist nonapeptide analogue of GnRH that possesses greater potency than the natural hormone. Note that it contains D-Ser(But) and NH-NHCONH2 in place of Gly6 and Gly10-NH2, respectively. That is, the C terminal modification simply has an NH substituting for the CH2 of Gly, and like the C-terminal change in leuprolide acetate, this inhibits enzymatic degradation of the peptide by the postproline carboxyamide peptidase.
Goserelin acetate is available in the form of a small, solid pellet that is administered as an SC implant for the palliative treatment of advanced, metastatic breast cancer in pre- and perimenopausal women or, similarly, as a palliative in advanced prostatic cancer. The rationale for this drug’s use is, as described above, its ability as a superagonist to bring the levels of estradiol or testosterone to near castrate levels, thus slowing the progression of breast or prostate carcinoma, respectively. Additionally, goserelin acetate is approved for use in treating endometriosis for up to 6 months.

Goserelin acetate CAS 145781-92-6 Chemical Properties
Melting point >190°C (dec.)
storage temp. -20°C
solubility H2O: 20 mg/mL, clear, colorless
form white powder
InChIKey IKDXDQDKCZPQSZ-JHYYTBFNSA-N
CAS DataBase Reference 145781-92-6

Function and Application Goserelin acetate CAS 145781-92-6
1. Anticancer
2. injectable gonadotropin releasing hormone superagonist (GnRH agonist) or luteinizing hormone antiproliferative activity in breast, prostate and endometrial cancers
3. Synthetic peptide agonist analog of LH-RH. Antineoplastic (hormonal).