High Quality Atosiban CAS 90779-69-4 is a combined contractin and pressin V1A receptor antagonist

High Quality Atosiban CAS 90779-69-4 is a combined contractin and pressin V1A receptor antagonist

Product Name: Atosiban
Synonyms: RW-22164;RW-22164;RWJ-22164;Atosiban Impurtiy;atosiban price;1-deamino-2d-tyr-(oet)-4-thr-8-orn-oxytocin;oxytocin,1-(3-mercaptopropanoicacid)-2-(o-ethyl-d-tyrosine)-4-l-threonine-8-l;rwj22164;ATOSIBAN ACETATE
CAS: 90779-69-4
MF: C43H67N11O12S2
MW: 994.19
EINECS: 806-815-5
Product Categories: hormones;Peptide
Mol File: 90779-69-4.mol

Atosiban was introduced in the UK as an injectable inhibitor of preterm labor, a major cause of infant morbidity and mortality. This peptidic oxytocin analog is an antagonist of the vasopressin V1a receptor and of the oxytocin receptor which is found in dramatically increased concentration in the uterine myometrium of pregnant women near term. It competitively inhibited contractions in the pregnant guinea pig uterus induced by oxytocin and vasopressin. In a multicenter, double-blind, placebo-controlled trial, treatment with atosiban caused pregnancy prolongation for up to 7 days in women with more than 28 weeks of gestation. In a comparative clinical trial, atosiban showed a comparable tocolytic action (uterine relaxant) to ritodrine but the former was significantly better tolerated, especially with regards to maternal cardiovascular side effects. In healthy volunteers, plasma levels of atosiban decreased bi-exponentially with an initial and a terminal half-life of 21 min and 1.7h respectively.

Atosiban is a combined receptor antagonist of contractin and pressin V1A. The structure of contractin receptor and pressin V1A receptor is similar. When the contractile hormone receptor is blocked, contractile hormone can still act through the V1A receptor, so it is necessary to block the above two receptor action pathways when the same Chemicalbook is used, and a single antagonism of one receptor can effectively inhibit uterine contraction. This is one of the main reasons why beta agonists, calcium channel blockers and prostaglandin synthase inhibitors do not effectively inhibit uterine contractions.

Atosiban CAS 90779-69-4 Chemical Properties
Boiling point 1469.0±65.0 °C(Predicted)
density 1.254±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility H2O: ≤100 mg/mL
form solid
pka 12.81±0.70(Predicted)
CAS DataBase Reference 90779-69-4(CAS DataBase Reference)

Function and Application of Atosiban CAS 90779-69-4
1. Premature labor
2. Atosiban is an oxytocin receptor blocking agent in the treatment of experimental endometriosis and was shown exhibit significant therapeutic efficiency.

Atosiban Anticancer Research The antitumor effects of the essential oil of O. falcata were tested in transplantedmurine H22 solid tumors in vivo. Growth inhibition in H22 solid tumors was moderate(Yang et al. 2013).