Carperitide Acetate/ ANP 1-28, HUMAN CAS 89213-87-6 For treatment of congestive heart failure

Carperitide Acetate/ ANP 1-28, HUMAN CAS 89213-87-6 For treatment of congestive heart failure

Product Name: Carperitide Acetate/ ANP 1-28, HUMAN
Sequence： H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH，(Disulfide bridge: Cys-Cys)
Synonyms: ATRIAL NATRIURETIC PEPTIDE HUMAN;SER-LEU-ARG-ARG-SER-SER-CYS-PHE-GLY-GLY-ARG-MET: O-ASP-ARG-ILE-GLY-ALA-GLN-SER-GLY-LEU-GLY-CYS-ASN-SER-PHE-ARG-TYR[SLRRSSCFGGR-MET: O-DRIGAQSGLGCNSFRY]DISULFIDE BRIDGE CYS7-CYS23.;Carperitide Acetate, carperitida;Atrial Natriuretic Peptide (1-28) (human) (trifluoroacetate salt);ahANF, Carperitide;H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH;Atrial natriureticpeptide-28 (huMan) (9CI);Atrial Natriuretic Factor (1-28) (huMan) αhANF, Carperitide
CAS: 89213-87-6
MF: C127H203N45O39S3
MW: 3080.44
EINECS: 686-482-9
Product Categories: peptide
Mol File: 89213-87-6.mol

Carperitide is a 28 amino acid polypeptide with a stable secondary structure and is a circulatory hormone that acts as a vasodilator and diuretic. In clinical practice, the vasodilation induced by carperitide as the main ingredient is due to binding to ANP (atrial natriuretic polypeptide) receptors in vascular smooth muscle, which is achieved by increasing the activity of guanylate cyclase, suggesting a reduction in cardiac pre and afterload.

Carperitide is the α-human atrial natriuretic peptide (α-hANP) produced by recombinant technology. It was introduced in Japan as a treatment for acute congestive heart failure (CHF). In dogs with CHF, carperitide significantly reduced the elevated left ventricular end-diastolic pressure and the index of myocardial oxygen consumption (systolic blood pressure x heart rate). In a clinical trial, carperitide was effective in improving hemodynamics and symptoms in 60% of patients with acute CHF. Carperitide was reported to be well tolerated with no significant adverse effects clinically. A beneficial effect on hemodynamics has been reported in chronic heart failure patients. Carperitide is also in clinical trials for maintenance of blood pressure during surgical operations.

Application
Treatment of decompensated congestive heart failure.