Angiotensin II/ ANGIOTENSIN II, HUMAN CAS 4474-91-3 For Blood pressure raising

Angiotensin II/ ANGIOTENSIN II, HUMAN CAS 4474-91-3 For Blood pressure raising

Product Name: ANGIOTENSIN II, HUMAN
Sequence: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Synonyms: DRVYIHPF;[ILE5]-ANGIOTENSIN 2;HYPERTENSION II HUMAN;L-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE;H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH;FLUORESCEIN-NHCS-NH-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH;ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH 2CH3CHOOH H2O;ANGIOTENSIN II, HUMAN
CAS: 4474-91-3
MF: C50H71N13O12
MW: 1046.2
EINECS: 2017-001-1
Product Categories: Angiotensin;peptide
Mol File: 4474-91-3.mol

It is known that tumor tissues including metastatic lymph nodes are composed of newly growing vessels which lack blood flow autoregulation and are influenced only secondarily by the responding somatic vessels. Human angiotensin II (AT II). a vasopressor, was introduced in Japan to improve the efficacy of systemic chemotherapy. In patients with various advanced cancers, i.v. infusion of AT II to achieve a mean blood pressure of 1.5 times of baseline (but not over 150 mm Hg) followed by a bolus injection of conventional cytotoxic agents increases blood flow 5-7 fold in tumor tissues and therefore, increases drug delivery to the target tissue resulting in enhanced chemotherapeutic effects. This induced-hypertension chemotherapy regimen can be performed safely with minimal side effects.

Angiotensin II/ ANGIOTENSIN II, HUMAN CAS 4474-91-3 Chemical Properties
Boiling point 809.08°C (rough estimate)
density 1.1257 (rough estimate)
refractive index 1.6700 (estimate)
RTECS BW2165000
storage temp. Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
form Powder
pka pK1: 10.37 (25°C)
color orange
Water Solubility Soluble in Water (25 mg/ml), and 5% Acetic Acid (1 mg/ml).
InChIKey CZGUSIXMZVURDU-JZXHSEFVSA-N
CAS DataBase Reference 4474-91-3

Function and Application of Angiotensin II/ ANGIOTENSIN II, HUMAN CAS 4474-91-3
Angiotensin II is a short peptide composed of 8 amino acids, and its physiological function is mainly to raise blood pressure by constricting small arteries throughout the body. In addition, it can also promote the secretion of aldosterone by the adrenal cortex, which acts on the renal tubules to preserve sodium, water and potassium, thus causing an increase in blood volume and blood pressure.

Uses of Angiotensin II/ ANGIOTENSIN II, HUMAN CAS 4474-91-3
1. Cardiopulmonary resuscitation – not yet an approved application
2. A peptide involved in the regulation of blood pressure
3. Angiotensin II is a peptide hormone known best as a vasoconstrictor with central roles in chronic hypertension, heart failure, and stroke. It is an octapeptide typically generated by the removal of two residues from angiotensin I by angiotensin-converting enzyme (ACE). Angiotensin II is a ligand for at least two distinct receptors, AT1 and AT2, each evoking distinct signaling pathways and physiological responses. The development of antagonists for specific angiotensin II receptor subtypes represents a valuable alternative to ACE inhibitors.