Enfuvirtide/ Enfuvirtide Acetate CAS 159519-65-0 For Anti HIV

Enfuvirtide/ Enfuvirtide Acetate CAS 159519-65-0 For Anti HIV

Product Name: Enfuvirtide
Sequence: Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys
-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2
Synonyms: Enfuvirtide; T-2;Enfuvirtide Acetate (T-20);ENFUVIRTIDE(T-20) 98+%;Enfurvitide(T-20);Pentafuside;Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH{2};Enfuvirtide;Aids059486
CAS: 159519-65-0
MF: C204H301N51O64
MW: 4491.92
EINECS: 641-385-0
Product Categories: proteins;Peptide
Mol File: 159519-65-0.mol

It is a synthetic peptide inhibitor of HIV fusion, which can bind to the viral envelope glycoprotein and prevent the conformational changes necessary for the virus to fuse with the cell membrane, thus inhibiting the replication of HIV-1.Enfevir peptide is derived from a naturally occurring amino acid sequence in the HR2 domain of gp41. By simulating the activity of the HR2 domain and competitively binding to the HR1 domain of gp41, Enfevir peptide prevents the interaction between HR1 and HR2 and changes in the configuration of the Gp41, thus preventing the fusion of the virus with host cells.

Enfuvirtide is the first of a new class of HIV therapeutics that interferes with the entry of HIV-1 by inhibiting fusion of viral and cellular membranes. It binds to the first heptad-repeat (HR1) in ghe gp41 subunit of the viral envelope glycoprotein and prevents the conformational changes required for the fusion with cell membranes, thus representing a new mechanism. It is a potent inhibitor of this binding with an IC50 in laboratory and primary isolates (HIV-1 clades A–G) ranging from 4 to 280 nM (18–1260 ng/mL), but has virtually no activity against HIV-2. Due to its unique mechanism, it does not show cross-resistance to NRTI, NNRTI and PIs. It is prepared by chemical synthesis, using a combination of solution and solid phase steps. The solid phase steps utilize fmoc protection and the acid sensitive 2- chlorotrityl chloride resin to produce peptides of lengths ranging from nine to sixteen amino acids.

Enfuvirtide/ Enfuvirtide Acetate CAS 159519-65-0 Chemical Properties
storage temp. -20°C
form powder
color white to off-white

Uses of Enfuvirtide/ Enfuvirtide Acetate CAS 159519-65-0
It is used in combination with reverse transcriptase drugs for human immunodeficiency virus (HIV) infection.